CALL FOR PAPERS Physiology and GI Cancer Mitochondrial STAT3 contributes to transformation of Barrett’s epithelial cells that express oncogenic Ras in a p53-independent fashion
نویسندگان
چکیده
Chunhua Yu, Xiaofang Huo, Agoston T. Agoston, Xi Zhang, Arianne L. Theiss, Edaire Cheng, Qiuyang Zhang, Alexander Zaika, Thai H. Pham, David H. Wang, Peter E. Lobie, Robert D. Odze, Stuart J. Spechler, and Rhonda F. Souza Esophageal Diseases Center, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas; Department of Medicine, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas; Department of Surgery, Veterans Affairs North Texas Health Care System and the University of Texas Southwestern Medical Center, Dallas, Texas; Department of Pathology, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massacusetts; Harold C. Simmons Comprehensive Cancer Center, University of Texas Southwestern Medical Center, Dallas, Texas; Baylor Research Institute, Baylor University Medical Center, Dallas, Texas; Department of Pediatrics, Children’s Medical Center and the University of Texas Southwestern Medical Center, Dallas, Texas; Departments of Surgery and Cancer Biology, Vanderbilt University Medical Center and the Vanderbilt-Ingram Cancer Center, Nashville, Tennessee; and Cancer Science Institute of Singapore, National University of Singapore, Yong Loo Lin School of Medicine, Singapore
منابع مشابه
Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashion.
Metaplastic epithelial cells of Barrett's esophagus transformed by the combination of p53-knockdown and oncogenic Ras expression are known to activate signal transducer and activator of transcription 3 (STAT3). When phosphorylated at tyrosine 705 (Tyr705), STAT3 functions as a nuclear transcription factor that can contribute to oncogenesis. STAT3 phosphorylated at serine 727 (Ser727) localizes ...
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